Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM.

@article{Tsai1994ReducedPP,
  title={Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM.},
  author={Elaine C Tsai and Irl B. Hirsch and John D. Brunzell and Alan Chait},
  journal={Diabetes},
  year={1994},
  volume={43 8},
  pages={1010-4}
}
Oxidation of low-density lipoproteins (LDLs) has been postulated to play an important role in atherogenesis. Because oxidant stress may be increased and antioxidant defenses reduced in diabetes, the susceptibility of LDL to oxidative modification and total peroxyl radical trapping potential (TRAP) of plasma were evaluated in subjects with poorly controlled insulin-dependent diabetes mellitus (IDDM). The lag phase of conjugated diene formation after initiation of LDL oxidation by the addition of… CONTINUE READING

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