Reduced plasma fibrin clot permeability and susceptibility to lysis in patients with inflammatory bowel disease: a novel prothrombotic mechanism.

@article{Owczarek2013ReducedPF,
  title={Reduced plasma fibrin clot permeability and susceptibility to lysis in patients with inflammatory bowel disease: a novel prothrombotic mechanism.},
  author={Danuta Owczarek and Dorota Cibor and Kinga Sałapa and Mikołaj Krzysztof Głowacki and Tomasz H. Mach and Anetta Undas},
  journal={Inflammatory bowel diseases},
  year={2013},
  volume={19 12},
  pages={
          2616-24
        }
}
BACKGROUND Inflammatory bowel disease (IBD) is associated with an increased risk of thromboembolism. Its mechanism is still unclear. Altered fibrin clot properties have been reported in patients with thromboembolism and those with chronic inflammatory states. We investigated whether fibrin characteristics are abnormal in IBD. METHODS Ex vivo plasma fibrin clot permeability (Ks), compaction, turbidity, and efficiency of fibrinolysis were assessed in 85 consecutive patients with IBD, including… CONTINUE READING
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