Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

@article{Noorman2013ReducedPI,
  title={Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.},
  author={M. Noorman and S. Hakim and Angeliki Asimaki and A. Vreeker and H. V. van Rijen and M. V. D. van der Heyden and N. de Jonge and R. D. de Weger and R. Hauer and J. Saffitz and T. V. van Veen},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={2013},
  volume={22 5},
  pages={
          314-8
        }
}
  • M. Noorman, S. Hakim, +8 authors T. V. van Veen
  • Published 2013
  • Biology, Medicine
  • Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • BACKGROUND Arrhythmogenic cardiomyopathy (AC) primarily is considered to be a desmosomal disease with a predominant right ventricular phenotype. Reduced signal intensity for junctional plakoglobin (JUP) at the intercalated disks has been proposed as a marker that contributes to diagnosis of the disease. In this technical study, we investigated how methodology-related differences caused by tissue preservation and antibody dilutions affect an appropriate diagnosis. METHODS Autopsy and biopsy… CONTINUE READING
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