Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress.

@article{Chandran2013ReducedPO,
  title={Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress.},
  author={Agata Chandran and Abiye H. Iyo and Courtney S Jernigan and Beata Legutko and Mark C. Austin and Beata Karolewicz},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2013},
  volume={40},
  pages={240-5}
}
The activity of the mammalian target of rapamycin (mTOR), an ubiquitously expressed serine/threonine kinase, is central to the regulation of translation initiation and, consequently protein synthesis required for long-term potentiation and new synaptic connections. Recent studies show that activation of the mTOR signaling pathway is required for the rapid antidepressant actions of glutamate N-methyl-d-aspartate (NMDA) receptor antagonists such as ketamine. Our prior work documented the first… CONTINUE READING