Reduced peptide bond pseudopeptide analogues of neurotensin.

  title={Reduced peptide bond pseudopeptide analogues of neurotensin.},
  author={S Doulut and Mareli Rodriguez and D Lugrin and F Vecchini and Patrick Kitabgi and Andr{\'e} Aumelas and Jean Mart{\'i}nez},
  journal={Peptide research},
  volume={5 1},
Pseudopeptide analogues of the C-terminal hexapeptide of neurotensin (H-Arg-Arg-Pro-Tyr-Ile-Leu-OH) were obtained by replacing each peptide bond by the reduced peptide bond CH2NH. The resulting analogues were then examined for their ability to inhibit binding of labeled neurotensin to new-born mouse brain membranes and for stimulation of guinea pig ileum contraction. Replacement of the Ile12-Leu13, Tyr11-Ile12, Pro10-Tyr11 and Lys9-Pro10 peptide bonds resulted in about 2000-, 3400-, 200- and… CONTINUE READING

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