Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.

@article{Kamei2004ReducedPH,
  title={Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.},
  author={Daisuke Kamei and Kiyofumi Yamakawa and Yui Takegoshi and Maya Mikami-Nakanishi and Yoshihito Nakatani and Sachiko Oh-ishi and Hidekazu Yasui and Yoshiaki Azuma and Noriyasu Hirasawa and Kazuo Ohuchi and Hiroshi Kawaguchi and Yukio Ishikawa and Toshiharu Ishii and Satoshi Uematsu and Shizuo Akira and Makoto Murakami and Ichiro Kudo},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 32},
  pages={33684-95}
}
We examined the in vivo role of membrane-bound prostaglandin E synthase (mPGES)-1, a terminal enzyme in the PGE2-biosynthetic pathway, using mPGES-1 knockout (KO) mice. Comparison of PGES activity in the membrane fraction of tissues from mPGES-1 KO and wild-type (WT) mice indicated that mPGES-1 accounted for the majority of lipopolysaccharide (LPS)-inducible PGES in WT mice. LPS-stimulated production of PGE2, but not other PGs, was impaired markedly in mPGES-1-null macrophages, although a low… CONTINUE READING
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