Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression

  title={Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression},
  author={Simona Negoias and Ilona Croy and Johannes C. Gerber and Sebastian Puschmann and K. Petrowski and Peter Joraschky and Thomas Hummel},

Magnetic resonance imaging study; does the olfactory bulb volume change in major depression?

The olfactory bulb values of patients diagnosed with major depression in accordance with DMS-IV criteria, are measured with MRI, and these values are compared with the values of healthy volunteers to see if there are any statistically significant changes.

Olfactory sulcal depth and olfactory bulb volume in patients with schizophrenia: an MRI study

Olfactory bulb volume was significantly decreased in patients with schizophrenia compared to healthy controls, as was their performance on the UPSIT, and a positive correlation was seen in patients between right bulb volume and UPSIT scores.

Correlation Between Olfactory Bulb Volume and Chronic Depression: A Magnetic Resonance Imaging Study

Olfactory bulb volumes are notably smaller in patients with chronic major depression treated only with SSRIs (fluoxetine, sertraline, citalopram, escitaloprams, paroxetines), which is the first study to reveal reduced olfactory bulbs volume.

Reduced olfactory bulb volume in adults with a history of childhood maltreatment.

Postnatal neurogenesis might be by reduced in CM, which may affect olfactory function of the brain in later life, and a reduced OB volume may enhance psychological vulnerability in the presence of adverse childhood conditions.

Olfactory bulb volume predicts therapeutic outcome in major depression disorder

OB volume may be a biological vulnerability factor for the occurrence and/or maintenance of depression, at least in women.

Symptoms of depression change with olfactory function

Olfactory loss is associated with symptoms of depression. The present study, conducted on a large cohort of mostly dysosmic patients, aimed to investigate whether improvement in olfactory performance

Investigating Olfactory Bulb Volume Reduction as a Potential Biomarker for Some Neuropsychiatric Disorders: A Narrative Review

This article reviewed studies on the association of olfactory bulb volume with depression, Alzheimer’s disease, Parkinson's disease, migraine, and multiple sclerosis and hypothesized that the reduction of o aroma bulb volume could be a biomarker for some disorders.

Orbitofrontal cortex and olfactory bulb volume predict distinct aspects of olfactory performance in healthy subjects.

A functional dissociation was observed, with central and peripheral mechanisms explaining different aspects of the observed behavioral variance in the olfactory subscores, and data suggest an important role of regional gray matter volume in the right orbitofrontal cortex and Olfactory bulb volume for olf factory performance in healthy individuals.

Olfactory Dysfunction

Olfactory disorders may be observed together with cognitive impairment in patients with major depressive disorder and OT was negatively correlated with subjective cognitive impairment and may serve as a determinant for subjective cognitive changes.



Reduced olfactory bulb volume in patients with schizophrenia.

The olfactory system may be a model system in which to study the neurobiology of the disorder, and patients with schizophrenia exhibit structural Olfactory deficits as well as functional olfaction deficits.

Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction

Findings indicate that smell deficits leading to a reduced sensory input to the olfactory bulb result in structural changes at the level of the bulb.

Correlation between olfactory bulb volume and olfactory function in children and adolescents

For the first time, the present study showed a correlation between OB volume and olfactory functions in children.

Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis--a longitudinal study.

Results of this study support the idea that stimulation of olfactory receptor neurons impacts on the cell death in the Olfactory bulb, not only in rodents but also in humans.

Olfactory bulb volumes in patients with idiopathic Parkinson’s disease   a pilot study

Results indicated that there is little or no difference between IPD patients and healthy controls in terms of OB volume, and these data support the idea that olfactory loss in IPD is not a primary consequence of damage to theOlfactory epithelium but rather results from central-nervous changes.

Posttraumatic olfactory dysfunction: MR and clinical evaluation.

Volumetric analysis showed that patients without smell function had greater volume loss in olfactory bulbs and tracts than did those posttraumatic patients who retained some sense of smell.

Depression resulting from olfactory dysfunction is associated with reduced sexual appetite--a cross-sectional cohort study.

It seems that depression caused by olfactory loss is the main cause for the self-reported decrease in sexual appetite as the onset of Olfactory dysfunction.