Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression

@article{Negoias2010ReducedOB,
  title={Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression},
  author={Simona Negoias and Ilona Croy and Johannes C. Gerber and Sebastian Puschmann and K. Petrowski and Peter Joraschky and Thomas Hummel},
  journal={Neuroscience},
  year={2010},
  volume={169},
  pages={415-421}
}

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References

SHOWING 1-10 OF 77 REFERENCES

Reduced olfactory bulb volume in patients with schizophrenia.

TLDR
The olfactory system may be a model system in which to study the neurobiology of the disorder, and patients with schizophrenia exhibit structural Olfactory deficits as well as functional olfaction deficits.

Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction

TLDR
Findings indicate that smell deficits leading to a reduced sensory input to the olfactory bulb result in structural changes at the level of the bulb.

Correlation between olfactory bulb volume and olfactory function in children and adolescents

TLDR
For the first time, the present study showed a correlation between OB volume and olfactory functions in children.

Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis--a longitudinal study.

TLDR
Results of this study support the idea that stimulation of olfactory receptor neurons impacts on the cell death in the Olfactory bulb, not only in rodents but also in humans.

Olfactory bulb volumes in patients with idiopathic Parkinson’s disease   a pilot study

TLDR
Results indicated that there is little or no difference between IPD patients and healthy controls in terms of OB volume, and these data support the idea that olfactory loss in IPD is not a primary consequence of damage to theOlfactory epithelium but rather results from central-nervous changes.

Posttraumatic olfactory dysfunction: MR and clinical evaluation.

TLDR
Volumetric analysis showed that patients without smell function had greater volume loss in olfactory bulbs and tracts than did those posttraumatic patients who retained some sense of smell.

Depression resulting from olfactory dysfunction is associated with reduced sexual appetite--a cross-sectional cohort study.

TLDR
It seems that depression caused by olfactory loss is the main cause for the self-reported decrease in sexual appetite as the onset of Olfactory dysfunction.
...