Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome

Abstract

Children with Down syndrome (DS) have increased susceptibility to infections and a high frequency of leukemia and autoimmune disorders, suggesting that immunodeficiency and immune dysfunction are integral parts of the syndrome. A reduction in B-cell numbers has been reported, associated with moderate immunodeficiency and normal immunoglobulin levels. Here… (More)
DOI: 10.1002/eji.201445049

8 Figures and Tables

Topics

  • Presentations referencing similar topics