Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome


Children with Down syndrome (DS) have increased susceptibility to infections and a high frequency of leukemia and autoimmune disorders, suggesting that immunodeficiency and immune dysfunction are integral parts of the syndrome. A reduction in B-cell numbers has been reported, associated with moderate immunodeficiency and normal immunoglobulin levels. Here… (More)
DOI: 10.1002/eji.201445049

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