Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.

@article{Matsumoto2009ReducedNA,
  title={Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.},
  author={Yasuharu Matsumoto and Volker Adams and Claudia Walther and Caroline Kleinecke and Peter Brugger and Axel Linke and T Walther and Friedrich W. Mohr and Gerhard A. Schuler},
  journal={European heart journal},
  year={2009},
  volume={30 3},
  pages={346-55}
}
AIMS Endothelial destruction and calcification primarily occur at the aortic side of the calcified aortic valves (AVs). This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs). METHODS AND RESULTS Fifteen patients with severe AS and 18 age-matched control subjects were enrolled. Senescence-associated beta-galactosidase activity was mostly… CONTINUE READING

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