Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.

@article{Lyssuk2007ReducedNA,
  title={Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.},
  author={Elena Yu Lyssuk and Anna V Torgashina and Sergey K Soloviev and Evgeny L Nassonov and Svetlana N Bykovskaia},
  journal={Advances in experimental medicine and biology},
  year={2007},
  volume={601},
  pages={113-9}
}
CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens controlling occurrence of autoimmune diseases. Recently, it has been shown that the transcription factor forkhead box P3 (FoxP3) is specifically expressed on CD4+CD25+ T cells. FoxP3 has been described as the master control gene for the development and function of Tregs. We characterized CD4+CD25+CTLA-4+FoxP3+ T cells in 43 patients with systemic lupus erythematosus (SLE). Twenty of them… CONTINUE READING