Reduced noradrenergic tone to the hypothalamic paraventricular nucleus contributes to the stress hyporesponsiveness of lactation.

@article{Toufexis1998ReducedNT,
  title={Reduced noradrenergic tone to the hypothalamic paraventricular nucleus contributes to the stress hyporesponsiveness of lactation.},
  author={Donna J Toufexis and K. V. Thrivikraman and Paul M. Plotsky and David A Morilak and Ning Huang and C D Walker},
  journal={Journal of neuroendocrinology},
  year={1998},
  volume={10 6},
  pages={417-27}
}
Lactation in mammals is accompanied by a marked decrease in stress responsiveness that we previously attributed, in part, to a reduction in noradrenergic (NA) innervation of hypothalamic paraventricular nucleus (PVN) neurons controlling neuroendocrine stress responses. In the present study, we compared in-vivo PVN catecholamine secretion by microdialysis between nonlactating and lactating females and tested the effects of NA alpha-1 and alpha-2 receptor antagonists (corynanthine and idazoxan… CONTINUE READING