Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.

@article{Recchia1998ReducedNO,
  title={Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.},
  author={Fabio A. Recchia and Patrick I. McConnell and Robert N. Bernstein and Todd R. Vogel and Xiaowei Xu and Thomas H. Hintze},
  journal={Circulation research},
  year={1998},
  volume={83 10},
  pages={
          969-79
        }
}
The aim of the present study was to determine whether cardiac nitric oxide (NO) production changes during the progression of pacing-induced heart failure and whether this occurs in association with alterations in myocardial metabolism. Dogs (n=8) were instrumented and the heart paced until left ventricular end-diastolic pressure reached 25 mm Hg and clinical signs of severe failure were evident. Every week, hemodynamic measurements were recorded and blood samples were withdrawn from the aorta… CONTINUE READING

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