Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome.

@article{Frisbee2005ReducedNO,
  title={Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome.},
  author={Jefferson C Frisbee},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={289 2},
  pages={
          R307-R316
        }
}
This study tested the hypothesis that chronically elevated oxidant stress contributes to impaired active hyperemia in skeletal muscle of obese Zucker rats (OZR) vs. lean Zucker rats (LZR) through progressive deteriorations in microvascular structure. Twelve-week-old LZR and OZR were given 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (tempol) in the drinking water for approximately 4 wk. Subsequently, perfusion of in situ gastrocnemius muscle was determined during incremental elevations in… CONTINUE READING
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Impaired skeletal muscle perfusion in obese Zucker rats.

American journal of physiology. Regulatory, integrative and comparative physiology • 2003
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