Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep.

@article{Singh2010ReducedNE,
  title={Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep.},
  author={Reetu R. Singh and Kate M. Denton and John F. Bertram and Andrew J. Jefferies and Karen M Moritz},
  journal={Clinical science},
  year={2010},
  volume={118 11},
  pages={669-80}
}
Reduced nephron endowment is associated with development of renal and cardiovascular disease. We hypothesized this may be attributable to impaired sodium homoeostasis by the remaining nephrons. The present study investigated whether a nephron deficit, induced by fetal uninephrectomy at 100 days gestation (term=150 days), resulted in (i) altered renal sodium handling both under basal conditions and in response to an acute 0.9% saline load (50 ml.kg-1 of body weight.30 min-1); (ii) hypertension… CONTINUE READING
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