Reduced myocardial 18F-FDG uptake after calcium channel blocker administration. Initial observation for a potential new method to improve plaque detection

@article{Gaeta2011ReducedM1,
  title={Reduced myocardial 18F-FDG uptake after calcium channel blocker administration. Initial observation for a potential new method to improve plaque detection},
  author={Chiara Gaeta and Yolanda Blanco Fern{\'a}ndez and Javier Pav{\'i}a and Albert Flotats and Carles Artigas and Jordi Deportos and Llanos Geraldo and Ignasi Carrio},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2011},
  volume={38},
  pages={2018-2024}
}
Physiological glucose uptake by the myocardium may hamper visualization of coronary atherosclerotic plaques in 18F-FDG PET studies. Intracellular myocardial calcium relates to glucose influx. We assessed whether administration of a calcium channel blocker such as verapamil could decrease myocardial 18F-FDG uptake in mice. Experiments were conducted on ten male C57BL/6JOlaHsd mice. The mice were studied by 18F-FDG PET/CT under basal conditions and after a single administration of verapamil… CONTINUE READING