Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients

Abstract

Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (−45%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle.

DOI: 10.1007/s00726-011-1165-y

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@article{Gualano2011ReducedMC, title={Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients}, author={Bruno Gualano and Inge Everaert and Sanne M Stegen and Guilherme Giannini Artioli and Youri E.C. Taes and Hamilton Augusto Roschel and Eric Achten and Maria Conc{\'e}pcion Garcia Otaduy and Antonio Herbert Lancha Junior and Roger Charles Harris and Wim Derave}, journal={Amino Acids}, year={2011}, volume={43}, pages={21-24} }