Reduced modeling of signal transduction – a modular approach

  title={Reduced modeling of signal transduction – a modular approach},
  author={Markus Koschorreck and Holger Conzelmann and Sybille Ebert and Michael Ederer and Ernst Dieter Gilles},
  journal={BMC Bioinformatics},
  pages={336 - 336}
Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively and a lot of progress has been made within the last few years. A software tool (BioNetGen) was developed which allows an automatic rule-based set-up of mechanistic model equations. In many cases these models can be reduced by an exact domain-oriented lumping technique. However, the resulting models can still consist of a very… CONTINUE READING