Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.

@article{Boudina2005ReducedMO,
  title={Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.},
  author={Sihem Boudina and Sandra Sena and Brian T. O'Neill and Prakash Tathireddy and Martin Elliot Young and E. Dale Abel},
  journal={Circulation},
  year={2005},
  volume={112 17},
  pages={2686-95}
}
BACKGROUND Obesity is a risk factor for cardiovascular disease and is strongly associated with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals demonstrated increased myocardial oxygen consumption (MVO2) and reduced cardiac efficiency (CE); however, the underlying mechanisms remain unclear. The present study was performed to determine whether mitochondrial dysfunction and uncoupling are responsible for reduced cardiac performance and efficiency in ob/ob mice… CONTINUE READING