Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients.

@article{Gos2014ReducedMI,
  title={Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients.},
  author={Tomasz Gos and Aye Mu Myint and Kolja Schiltz and Gabriela Meyer-Lotz and Henrik Dobrowolny and Stefan Busse and Ulf J. M{\"u}ller and Christian Mawrin and H. G. Bernstein and Bernhard Bogerts and Johann Steiner},
  journal={Brain, behavior, and immunity},
  year={2014},
  volume={41},
  pages={59-64}
}
Postmortem and positron emission tomography studies have indicated the pathophysiological involvement of microglial cells in schizophrenia. We hypothesized that the microglial production of quinolinic acid (QUIN), an endogenous N-methyl-d-aspartate receptor (NMDAR) agonist, may be linked to the previously described glutamatergic deficits in the hippocampus of schizophrenia patients. We performed a semi-quantitative assessment of QUIN-immunoreactive microglial cells in schizophrenia patients and… CONTINUE READING
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