Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

@article{Lee2006ReducedMC,
  title={Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.},
  author={Young Joo Lee and William J. Jusko and Christine G. Salaita and Karim Anton Calis and Michael W. Jann and Vicky E. Spratlin and Joyce A. Goldstein and Yuen Yi Hon},
  journal={Journal of clinical pharmacology},
  year={2006},
  volume={46 5},
  pages={515-26}
}
The influence of diet and genetics was investigated in a healthy white person who had distinctly low methylprednisolone clearance. Pharmacokinetic and pharmacodynamic parameter values were similar on 2 occasions during the consumption of a low-carbohydrate diet and a Weight Watchers diet, indicating that the decreased clearance was unlikely attributable to a change in diet composition. Although the subject was found to be homozygous for CYP3A5*3, genetic findings were not significant for a… CONTINUE READING