Reduced mRNA for G3BP in fragile X cells: evidence of FMR1 gene regulation.

@article{Zhong1999ReducedMF,
  title={Reduced mRNA for G3BP in fragile X cells: evidence of FMR1 gene regulation.},
  author={N A Zhong and Weina Ju and Deirdre A. Nelson and Carl Dobkin and William Ted Brown},
  journal={American journal of medical genetics},
  year={1999},
  volume={84 3},
  pages={
          268-71
        }
}
  • N A Zhong, Weina Ju, +2 authors William Ted Brown
  • Published in
    American journal of medical…
    1999
  • Medicine, Biology
  • Although fragile X syndrome is caused by the absence of fragile X gene expression, little is known about the pathogenic processes underlying the mental retardation. Recent findings that the fragile X protein, FMRP, contains RNA binding motifs and nuclear transport signals and associates with ribosomes suggest that FMRP may be involved in either mRNA processing, transport, or translation. To test the hypothesis that absence of FMRP may affect the processing of specific transcripts, we have used… CONTINUE READING

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