Reduced mRNA and protein expression of BCL-2 versus decreased mRNA and increased protein expression of BAX in breast cancer brain metastases: a real-time PCR and immunohistochemical evaluation.

@article{Stark2006ReducedMA,
  title={Reduced mRNA and protein expression of BCL-2 versus decreased mRNA and increased protein expression of BAX in breast cancer brain metastases: a real-time PCR and immunohistochemical evaluation.},
  author={Andreas Martin Stark and Saskia Pfannenschmidt and Hauke Tscheslog and Nicola{\`i} Maass and Frank Roesel and H. Maximilian Mehdorn and Janka Held-Feindt},
  journal={Neurological research},
  year={2006},
  volume={28 8},
  pages={787-93}
}
OBJECTIVES Brain metastases are an increasingly common complication in breast cancer patients. Apoptosis regulating genes are promising candidates for further treatment options. We examined the mRNA and protein expression of p53, BCL-2 and BAX in breast cancer brain metastases versus primary tumors. METHODS In a two-step approach p53, BCL-2 and BAX mRNA expression in ductal invasive breast cancer brain metastases was examined by: (1) reverse transcription-polymerase chain reaction (RT-PCR… CONTINUE READING

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