Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.

@article{Hauck2001ReducedLO,
  title={Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.},
  author={Steve Hauck and William Samuel Hunter and Natalia Danilovich and John J. Kopchick and Andrzej Bartke},
  journal={Experimental biology and medicine},
  year={2001},
  volume={226 6},
  pages={
          552-8
        }
}
The mechanisms that are responsible for the extension of lifespan in the mouse with targeted disruption (knockout [KO]) of the growth hormone (GH) receptor/binding protein (GHR-KO) are unknown. However, in the long-living Ames dwarf mouse, blood glucose and body core temperature (Tco) are consistently lower than in normal mice. In addition, insulin levels are reduced and corticosterone levels are elevated in male dwarfs. These functional alterations, similar to those seen in animals under… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 62 CITATIONS, ESTIMATED Infinity% COVERAGE

62 Citations

02468'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 62 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…