Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

@article{Arimura2009ReducedLO,
  title={Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.},
  author={Sumimasa Arimura and Akihiro Matsunaga and Takanori Kitamura and Koji Aoki and Masahiro Aoki and Makoto Mark Taketo},
  journal={Gastroenterology},
  year={2009},
  volume={137 2},
  pages={629-38}
}
BACKGROUND & AIMS Although the Hedgehog (Hh) pathway regulates development and progression of several types of cancer, its involvement in colon cancer remains unclear. We aimed to clarify the roles of Hh signaling in intestinal tumorigenesis. METHODS We studied expression of the Hh signaling components in the intestinal tumors of Apc(+/Delta716) mouse, a model for familial adenomatous polyposis. We used small interfering RNAs against Smoothened (SMO), which encodes the major signal transducer… CONTINUE READING
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