Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity.

@article{Sande2002ReducedLO,
  title={Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity.},
  author={J\orn Bodvar Sande and Ivar Sjaastad and Ingvild B Hoen and Janny B\okenes and Theis T\onnessen and Even Holt and Per Kristian Lunde and Geir Christensen},
  journal={Cardiovascular research},
  year={2002},
  volume={53 2},
  pages={382-91}
}
OBJECTIVE Heart failure is associated with alterations in contractile parameters and accompanied by abnormalities in intracellular calcium homeostasis. Sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) and phospholamban (PLB) are important in intracellular calcium cycling. The aim of the present study was to examine mechanisms causing reductions in SERCA2 activity in the failing heart. METHODS Myocardial infarction (MI) was induced in male Wistar rats, and animals with congestive heart failure… CONTINUE READING

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Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
Myocardial infarction ( MI ) was induced in male Wistar rats , and animals with congestive heart failure were examined 6 weeks after the primary operation .
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