Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice.

@article{Gregory2004ReducedLC,
  title={Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice.},
  author={Julia L Gregory and Michelle T. Leech and John R. David and Yuan Hang Yang and April Dacumos and Michael J Hickey},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 9},
  pages={3023-34}
}
OBJECTIVE Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with established roles in a range of inflammatory conditions. However, it is not known whether MIF influences inflammation via the direct promotion of leukocyte-endothelial cell interactions. Therefore, the aim of these experiments was to investigate the ability of MIF to regulate leukocyte-endothelial cell interactions in the inflamed microvasculature. METHODS Intravital microscopy was used to examine… CONTINUE READING
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