Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.

@article{Millar1975ReducedLI,
  title={Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.},
  author={John L. Millar and Barry N. Hudspith and Norman Blackett},
  journal={British Journal of Cancer},
  year={1975},
  volume={32},
  pages={193 - 198}
}
Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery. 

From This Paper

Topics from this paper.
17 Citations
13 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

The Effect of Fetuin and of Spleen Extracts on Haematopoietic Precursors and on Differentiated Hematopoietic Cells in Irradiated Mice

  • R. DONS, W. H. KNoSPE, W. FRIED
  • Cell tissue Kinet .
  • 1974
1 Excerpt

Effect of a Noncellular Spleen-derived Factor on Recovery of Haemopoietic Stem

  • H W., W. FRIED, S. A. GREGORY, R. J. SASSETTI, TROBAUGH, F. E.
  • 1970

On Mouse Strain Differences in Radiation Resistance: Haemopoietic Death and Endogenous Colonyforming Units

  • J. B. STORER
  • Radiat . Res .
  • 1969
1 Excerpt

Further Studies on the Effect of Serum Alpha Macroglobulin on Regeneration of Haemopoietic Tissue after Xirradiation

  • D. H. PLUZNIK, L. SACHS
  • Radiat . Res .
  • 1968

The Effect of Cyclophosphamide on Hematopoietic Stem Cells

  • W. H. KNOSPE
  • Radiat . Res .
  • 1968

Similar Papers

Loading similar papers…