Reduced leptin levels in starvation increase susceptibility to endotoxic shock.

@article{Faggioni2000ReducedLL,
  title={Reduced leptin levels in starvation increase susceptibility to endotoxic shock.},
  author={Raffaella Faggioni and Arthur H. Moser and Kenneth R. Feingold and Carl Grunfeld},
  journal={The American journal of pathology},
  year={2000},
  volume={156 5},
  pages={
          1781-7
        }
}
Malnutrition compromises immune function, reducing resistance to infection. We examine whether the decrease in leptin induced by starvation increases susceptibility to lipopolysaccharide (LPS)- and tumor necrosis factor (TNF)-induced lethality. In mice, fasting for 48 hours enhances sensitivity to LPS. Decreasing the fasting-induced fall in leptin by leptin administration markedly reduced sensitivity to LPS. Although fasting decreases basal leptin levels, LPS treatment increased leptin to the… CONTINUE READING
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