Reduced length-dependent cross-bridge recruitment in skinned fiber preparations of human failing myocardium

@article{Brixius2003ReducedLC,
  title={Reduced length-dependent cross-bridge recruitment in skinned fiber preparations of human failing myocardium},
  author={Klara Brixius and Persephone Savidou-Zaroti and Wilhelm Bloch and Robert H. G. Schwinger},
  journal={European Journal of Applied Physiology},
  year={2003},
  volume={89},
  pages={249-256}
}
A depressed activity of myosin ATPase has been described in human failing myocardium. Since alterations in cross-bridge kinetics may affect both systolic and diastolic cardiac function, the present study simultaneously investigated Ca2+-dependent tension and actomyosin ATPase activity (MYO) in triton X-skinned fiber preparations of human non-failing (donor hearts, n=8) and failing (dilated cardiomyopathy, n=11) left ventricular myocardium at increasing sarcomeric length (1.9 and 2.1 µm… CONTINUE READING