Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia.

@article{Casanello2009ReducedLT,
  title={Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia.},
  author={Paola Casanello and Bernardo Krause and Eneida Pena Pereira Torres and Victoria I Gallardo and Miriam Soto Gonz{\'a}lez and Cedano Prieto and Carlos Escudero and Marcelo Far{\'i}as and Luis Sobrevia},
  journal={Placenta},
  year={2009},
  volume={30 7},
  pages={
          625-33
        }
}
Intrauterine growth restriction (IUGR) is associated with chronic fetal hypoxia, altered placental vasodilatation and reduced endothelial nitric oxide synthase (eNOS) activity. In human umbilical vein endothelial cells (HUVEC) from pregnancies complicated with IUGR (IUGR cells) and in HUVEC from normal pregnancies (normal cells) cultured under hypoxia l-arginine transport is reduced; however, the mechanisms leading to this dysfunction are unknown. We studied hypoxia effect on l-arginine… CONTINUE READING
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