Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

@article{Schielke1998ReducedIB,
  title={Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.},
  author={Gerald Paul Schielke and Guo-Yuan Yang and Brenda De Rae Shivers and Anthony Betz},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1998},
  volume={18 2},
  pages={
          180-5
        }
}
A variety of recent studies suggest a role for both inflammatory cytokines such as interleukin-1 beta (IL-1 beta), and apoptosis in ischemic brain injury. Because IL-1 beta converting enzyme (ICE) is required for the conversion of proIL-1 beta to its biologically active form, and has homology with proteins that regulate apoptosis in invertebrates, we studied the effect of cerebral ischemia on brain injury in mutant mice deficient in the ICE gene (ICE knockout [KO] mice). Focal cerebral ischemia… CONTINUE READING

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