Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers.

  title={Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers.},
  author={Timothy A. Johnson and Nathan A Stasko and Jessica L. Matthews and Wayne E. Cascio and Ekhson L. Holmuhamedov and Christopher B. Johnson and Mark H Schoenfisch},
  journal={Nitric oxide : biology and chemistry},
  volume={22 1},
We report the therapeutic potential of S-nitroso-N-acetylpenicillamine-derivatized generation-4 polyamidoamine dendrimers (G4-SNAP) for reducing ischemia/reperfusion (I/R) injury in an isolated, perfused rat heart. The use of this dendrimer scaffold to deliver the nitrosothiol therapeutic did not inhibit NO donor activity as the required dose of G4-SNAP to minimize I/R injury (31nM corresponding to 2microM SNAP) was consistent with the optimum concentration of small molecule SNAP alone. An… CONTINUE READING


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