Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.

@article{Marsh2010ReducedintensityCS,
  title={Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.},
  author={Rebecca A Marsh and Gretchen Chase Vaughn and Mi-Ok Kim and Dandan Li and Sonata Jodele and Sarita A Joshi and Parinda A Mehta and Stella M. Davies and Michael B. Jordan and Jack Jan Hendrik Bleesing and Alexandra H. Filipovich},
  journal={Blood},
  year={2010},
  volume={116 26},
  pages={5824-31}
}
Recent experience suggests that reduced-intensity conditioning (RIC) regimens can improve the outcomes of patients with hemophagocytic lymphohistiocytosis (HLH) undergoing allogeneic hematopoietic cell transplantation (HCT). However, studies directly comparing RIC to myeloablative conditioning (MAC) regimens are lacking. Forty patients with HLH underwent allogeneic HCT between 2003-2009 at Cincinnati Children's Hospital. Fourteen patients received MAC consisting of busulfan, cyclophosphamide… CONTINUE READING