Reduced-intensity conditioning allogeneic transplantation is associated with a high incidence of extramedullary relapses in multiple myeloma patients

@article{PrezSimn2006ReducedintensityCA,
  title={Reduced-intensity conditioning allogeneic transplantation is associated with a high incidence of extramedullary relapses in multiple myeloma patients},
  author={Jos{\'e} Antonio P{\'e}rez-Sim{\'o}n and Anna Sureda and Francesc Fern{\'a}ndez-Avil{\'e}s and Ant{\`o}nia Sampol and Janel R Cabrera and Dolores D Caballero and Rodrigo Martino and Jean-Michel Petit and Jos{\'e} Francisco Tom{\'a}s and Jose M Moraleda and A Monte Alegre and Consuelo del Ca{\~n}izo and Salut Brunet and Laura Rosi{\~n}ol and J Lahuerta and Justo D{\'i}ez-Mart{\'i}n and Anne L{\'e}on and Adriana Garc{\'i}a and Lourdes V{\'a}zquez and Jorge Sierra and J F San Miguel},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={542-545}
}
panied by changes in gene expression that included downregulation of PIM1. This suggests that the high expression levels of PIM1 seen in this tumor type, at least partly, are caused by transcriptional activation. However, other mutations of the genome than a mere increase in copy number could also lead to activation of the proto-oncogene, and PIM1 has been shown to be involved in translocations as well as to be a subject for hypermutations in lymphomas. The highest number of PIM1 copies… CONTINUE READING
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