Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysis.

@article{Flynn2007ReducedIC,
  title={Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysis.},
  author={Catherine M. Flynn and Betsy Hirsch and Todd E Defor and Juliet Barker and Jeffrey S Miller and John E Wagner and Bruce R Blazar and Linda Jean Burns and Margaret L Macmillan and Mukta Arora and Daniel J. Weisdorf},
  journal={American journal of hematology},
  year={2007},
  volume={82 10},
  pages={867-72}
}
We evaluated the efficacy of hematopoietic stem cell transplantation (HSCT) using reduced intensity (RI) vs. myeloablative (MA) conditioning for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome. Thirty two patients (median age 54) who underwent a RI HSCT (2000-2003) were compared with 187 patients (median age 39) who received a MA transplant (1990-2003). Neutrophil engraftment was more rapid in the RI group (median 11.5 vs. 21 days). Platelet recovery was similar and… CONTINUE READING
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