Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes.

@article{Wei2015ReducedIS,
  title={Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes.},
  author={Christina Wei and Manigandan S Thyagiarajan and Linda P. Hunt and Julian P. H. Shield and Michael C. G. Stevens and Elizabeth Clare Crowne},
  journal={Pediatric blood & cancer},
  year={2015},
  volume={62 11},
  pages={1992-9}
}
BACKGROUND Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have a high cardiometabolic risk despite lacking overt clinical obesity. This study characterised body composition using different methodologies and explored associations with reduced insulin sensitivities in a group of ALL survivors treated with/without HSCT/TBI. PROCEDURE Survivors of childhood ALL treated with HSCT/TBI (n = 20,10… CONTINUE READING
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