Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

@article{Andersson2012ReducedIS,
  title={Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes},
  author={Sofia A. Andersson and Anders H. Olsson and Jonathan L S Esguerra and Emilia Heimann and Claes Ladenvall and Anna K Edlund and Albert Salehi and Jalal Taneera and Eva Degerman and Leif Groop and Charlotte Ling and Lena Eliasson},
  journal={Molecular and Cellular Endocrinology},
  year={2012},
  volume={364},
  pages={36-45}
}
Reduced insulin release has been linked to defect exocytosis in β-cells. However, whether expression of genes suggested to be involved in the exocytotic process (exocytotic genes) is altered in pancreatic islets from patients with type 2 diabetes (T2D), and correlate to insulin secretion, needs to be further investigated. Analysing expression levels of 23 exocytotic genes using microarray revealed reduced expression of five genes in human T2D islets (χ(2)=13.25; p<0.001). Gene expression of… CONTINUE READING