Reduced inhibitory effects of clonidine and neuropeptide Y on3H-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat

The release of3H-noradrenaline (3H-NA) evoked by high-K+ (15 mM) was studied in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto and spontaneously hypertensive male rat (14 weeks old) using a superfusion apparatus. Based on concentration-response curves clonidine was shown to have a reduced ability to inhibit3H-NA release in… (More)