Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.

@article{Coppola2005ReducedIV,
  title={Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.},
  author={Antonio Coppola and Armando D'angelo and Isabella Fermo and Giuseppina Mazzola and Matteo Nicola Dario Di Minno and Alessia Cajani and Angelo Sala and Giancarlo Folco and Elena Tremoli and Giovanni di Minno},
  journal={British journal of haematology},
  year={2005},
  volume={131 1},
  pages={100-8}
}
The protective role of folate in vascular disease has been related to antioxidant effects. In 45 patients with previous early-onset (at age <50 years) thrombotic episodes and the 677TT methylenetetrahydrofolate reductase genotype, we evaluated the effects of a 28 d-course (15 mg/d) of 5-methyltetrahydrofolate (MTHF) on homocysteine metabolism and on in vivo… CONTINUE READING