Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia.

Abstract

Plasmodium falciparum malaria causes 1-2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM) (coma). Red cells of children with severe malaria-associated anemia (SMA) have acquired deficiencies in the complement regulatory proteins complement receptor 1 (CR1, CD35) and decay accelerating… (More)
DOI: 10.2119/2007-00093.Owuor

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