Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution.

@article{Michel2000ReducedIA,
  title={Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution.},
  author={Pascal Michel and Aissatou Toure Balde and Christian Roussilhon and Georgette Aribot and Jean Louis Sarthou and M L Gougeon},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 1},
  pages={64-75}
}
This study analyzes the degree of immune activation and characterizes apoptosis in lymphocytes from healthy West African donors or patients infected with human immunodeficiency virus (HIV)-1 or -2. The lower decline of CD4 T cells in HIV-2- compared with HIV-1-infected donors is associated with lower levels of immune activation, evaluated by HLA-DR expression on lymphocytes and sera concentrations of IgG and beta2 microglobulin (beta2m). Ex vivo apoptosis was found in both infections in all… CONTINUE READING

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