Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice

@article{Lee2004ReducedHE,
  title={Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice},
  author={Michelle Dongeun Lee and Elizabeth M. Somerville and Guy A. Kennett and Colin Trevor Dourish and Peter G. Clifton},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={39-49}
}
The possible role of compensatory changes in 5-HT2C receptors in the reduced hypophagic action of d-fenfluramine in 5-HT1B knockout (KO) mice was assessed by comparing their response to d-fenfluramine and the 5-HT2C receptor agonist mCPP. In addition we measured 5-HT2C/A receptor binding in 5-HT1B KO and wild-type (WT) mice and examined the effects of 5-HT1B receptor antagonists on d-fenfluramine-induced hypophagia in WT mice. Hypophagic responses to d-fenfluramine (1–30 mg/kg) and mCPP (1–5.6… CONTINUE READING

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Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from antagonist studies and CP-94,253induced c-fos immunoreactivity

  • MD Lee, GA Kennett, CT Dourish, PG Clifton
  • Appetite
  • 2003
Highly Influential
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