Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis
- Published 2002 in Journal of Molecular Medicine
Abstract
Hypertension-induced damage of kidney and heart is of major clinical relevance, but its pathophysiology is only partially understood. As there is considerable evidence for involvement of angiotensin II, we generated a new mouse model by breeding angiotensinogen (AOGEN) deficient mice with transgenic animals expressing the rat AOGEN gene only in brain and… (More)
