Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis

Abstract

Hypertension-induced damage of kidney and heart is of major clinical relevance, but its pathophysiology is only partially understood. As there is considerable evidence for involvement of angiotensin II, we generated a new mouse model by breeding angiotensinogen (AOGEN) deficient mice with transgenic animals expressing the rat AOGEN gene only in brain and… (More)
DOI: 10.1007/s00109-002-0326-6

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