Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

@inproceedings{OSullivan2010ReducedHB,
  title={Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres},
  author={Roderick J. O’Sullivan and Stefan Kubicek and Stuart L. Schreiber and Jan Karlseder},
  booktitle={Nature Structural &Molecular Biology},
  year={2010}
}
During replicative aging of primary cells morphological transformations occur, the expression pattern is altered and chromatin changes globally. Here we show that chronic damage signals, probably caused by telomere processing, affect expression of histones and lead to their depletion. We investigated the abundance and cell cycle expression of histones and histone chaperones and found defects in histone biosynthesis during replicative aging. Simultaneously, epigenetic marks were redistributed… CONTINUE READING
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