Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis

  title={Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis},
  author={Tomas Hajek and Miloslav Kope{\vc}ek and Cyril H{\"o}schl},
  journal={The World Journal of Biological Psychiatry},
  pages={178 - 187}
Abstract Objectives. Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size. Methods. We performed a meta-analysis of studies investigating the association between Val66Met BDNF polymorphism and hippocampal volumes in healthy subjects by combining standardized differences between means (SDM… 
Effect of the BDNF Val66Met Polymorphism on Regional Gray Matter Volumes and Cognitive Function in the Chinese Population
It is suggested that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.
Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults
A unique pattern of brain morphologic differences caused by BDNF (rs6265) in young Chinese adults is indicated, in which the Met/Met genotype markedly affected the frontal, temporal, cingulate, and insular regions.
Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity
The results underscore the importance of the interaction between physical activity and the BDNF Val66Met polymorphism, which affects the plasticity of neural mechanisms.
Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients
The findings suggest the BNDF Val66Met polymorphism may have a protective role in MS patients against both hippocampal atrophy and cognitive impairment and may be an interesting target to study for neuroprotective strategies.
BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
It is found that val66met substitution in BDNF correlated longitudinally with the rate of decline in SFSS, and this polymorphism could be used as a predictor of the effects of age on the structure of the hippocampus in healthy individuals.
Modulating effect of Val66Met polymorphism of brain-derived neurotrophic factor gene on clinical and psychological characteristics of patients with schizophrenia
In patients with higher anxiety, performance on cognitive tests did not depend on the genotype, while in patients with lower levels of anxiety, the ValVal genotype was associated with significantly better performance, and this effect should be taken into account when studying associations of the Val66Met polymorphism with cognitive functions in Patients with schizophrenia.
Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population
It is found that the BDNF rs6265 polymorphism was related to the severity of depressive symptoms, and that this association was independent of neurotransmitter levels, the first-time report a missing mediating role of neurotransmitters in this association.


Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients
Val homozygote genotype may serve as a vulnerability factor in MDD regarding hippocampal volume loss and can be considered as a supportive evidence for the neurotrophic factor hypothesis of depression.
Effects of brain‐derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
The results suggest that the BDNF Val66Met polymorphism is not associated with hippocampal volume change over time, and may support the possibility that BDNF affects brain morphology differently in schizophrenia patients and healthy subjects.
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression
It is demonstrated that the impact of the BDNF Val66Met polymorphism is not confined to the hippocampus but also extends to the parahippocampal gyrus and the amygdala.
Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.
Findings from animal studies that the hippocampus is involved in brain development and plasticity are supported, suggesting that Met-BDNF allele carriers might be at risk to develop smaller hippocampal volumes and may be susceptible to major depression.
Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness
It is suggested that even in otherwise healthy subjects, trait depression may contribute to the susceptibility of Met carriers to hippocampal grey matter loss.
The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.
  • S. Benjamin, D. Mcquoid, W. Taylor
  • Psychology, Biology
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2010
The BDNF Val66Met polymorphism is not significantly associated with hippocampal volume or function in a geriatric population, and the authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals.
Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder
An association between the BDNF Val66Met genotype and differential gray matter content in brain structures is supported, and the variation in this gene may play a more prominent role in brain structure differences in subjects affected with BD.
The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
The findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers.