Corpus ID: 25958863

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

@article{Sakimura1995ReducedHL,
  title={Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.},
  author={K. Sakimura and T. Kutsuwada and I. Ito and T. Manabe and C. Takayama and E. Kushiya and T. Yagi and S. Aizawa and Y. Inoue and H. Sugiyama},
  journal={Nature},
  year={1995},
  volume={373 6510},
  pages={
          151-5
        }
}
The NMDA (N-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluR epsilon (NR2) and GluR zeta (NR1) subunit families. The four epsilon subunits are distinct in distribution, properties and regulation. On the basis of the Mg2+ sensitivity and expression patterns, we have proposed that… Expand
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