Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

@article{Sakimura1995ReducedHL,
  title={Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.},
  author={Kenji Sakimura and Tatsuya Kutsuwada and Isao Ito and Toshiya Manabe and Chitoshi Takayama and Etsuko Kushiya and Takeshi Yagi and Shinichi Aizawa and Yoshiro Inoue and Hiroyuki Sugiyama},
  journal={Nature},
  year={1995},
  volume={373 6510},
  pages={151-5}
}
The NMDA (N-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluR epsilon (NR2) and GluR zeta (NR1) subunit families. The four epsilon subunits are distinct in distribution, properties and regulation. On the basis of the Mg2+ sensitivity and expression patterns, we have proposed that… CONTINUE READING
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