Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

@article{Sakimura1995ReducedHL,
  title={Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor $\epsilon$1 subunit},
  author={K. Sakimura and T. Kutsuwada and I. Ito and T. Manabe and C. Takayama and E. Kushiya and T. Yagi and S. Aizawa and Y. Inoue and H. Sugiyama and M. Mishina},
  journal={Nature},
  year={1995},
  volume={373},
  pages={151-155}
}
THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluRε (NR2) and GiuRζ (NR1) sub-unit families3–8. The four ε subunits are distinct in distribution, properties and regulation5–14. On the basis of the Mg2+ sensitivity and expression patterns, we have proposed that the εi… Expand
[Analysis of neuronal functions in mice lacking the NMDA receptor epsilon 1 subunit].
GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
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