Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.

@article{Chen2013ReducedHB,
  title={Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.},
  author={Zhu Chen and Xiang-Pei Li and Zhi-jun Li and Liang Ming Xu and Xiao-mei Li},
  journal={International immunopharmacology},
  year={2013},
  volume={15 3},
  pages={
          474-7
        }
}
Combination use of methotrexate (MTX) and leflunomide (LEF) has been proved effective in the treatment of active rheumatoid arthritis (RA). However, previous trials have documented that both are associated with increased incidence of liver toxicity. As active compounds extracted from the roots of the traditional Chinese herb Paeonia lactiflora Pall, total glucosides of paeony (TGP) have been shown to have anti-inflammatory, hepatoprotective and immuno-regulatory activities, without evident… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Total glucosides of paeony for rheumatoid arthritis: A systematic review of randomized controlled trials.

  • Complementary therapies in medicine
  • 2017
VIEW 13 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

safety of total glucosides of paeony combined with methotrexate and le fl unomide for active rheumatoid arthritis : a meta-analysis

Yao Huang, Hui Wang, +6 authors Shenghao
  • 2019
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Selective suppression of microglial activation by paeoniflorin attenuates morphine tolerance.

  • European journal of pain
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Medicinal Value Analysis of Peony Flower

  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND