Reduced haloperidol/haloperidol ratios in plasma: Polymorphism in Japanese psychiatric patients

@article{Someya1990ReducedHR,
  title={Reduced haloperidol/haloperidol ratios in plasma: Polymorphism in Japanese psychiatric patients},
  author={Toshiyuki Someya and Saburo Takahashi and Morikazu Shibasaki and Tadanobu Inaba and Siu Wa Tang},
  journal={Psychiatry Research},
  year={1990},
  volume={31},
  pages={111-120}
}
We measured plasma concentrations of haloperidol (HAL) and its metabolite, reduced haloperidol (RHAL), by high performance liquid chromatography (HPLC) in 45 Japanese psychiatric patients receiving HAL. Plasma levels of HAL had a highly positive correlation with daily dose per body weight. Plasma RHAL/HAL ratios had also a dose-dependent relationship, but their distribution was nonnormal and a bimodal pattern with an antimode at 0.7 was apparent by probit analysis. There were 8 subjects (18… CONTINUE READING

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Dose-dependent reduced haloperidol/haloperidol ratios in schizophrenic patients

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In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.

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