Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.

Abstract

Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial navigation, particularly grid cells, are impaired. Grid-cell-like representations in humans can be measured using functional magnetic resonance imaging. We found that young… (More)
DOI: 10.1126/science.aac8128

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